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July 10, 1937


JAMA. 1937;109(2):136. doi:10.1001/jama.1937.02780280042016

Clinicians of fifty years ago often noted improvement in the symptoms of pulmonary tuberculosis during pregnancy. Some even went so far as to recommend pregnancy as a therapeutic device for tuberculous girls. The alleged beneficial effects of pregnancy in tuberculosis have been tested on laboratory animals. Jameson,1 Muller, Burke and Bogen, and others report that in their hands pregnancy has had a favorable action in tuberculous guinea-pigs. Other investigators, however, deny this but agree that pregnancy has little or no injurious effects in tuberculous animals.

Since changes in endocrine balance are prominent features of pregnancy, Steinbach and Klein2 of the Josiah Macy Jr. Foundation, Columbia University, have tested the possible therapeutic effects of commercially available sex-endocrine products on tuberculous rabbits and guinea-pigs. The preparations thus far tested by them include (1) blood serum of four month pregnant mares, (2) two gonadotropic extracts of human pregnancy urine, (3) anterior

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