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March 5, 1932


JAMA. 1932;98(10):818. doi:10.1001/jama.1932.02730360040011

While, a priori, the total loss of any one of the digestive fluids should not prevent entirely the conversion of the foodstuffs to assimilable forms, the chemical characteristics of certain of these secretions, apart from the content of appropriate hydrolytic enzymes, are such that total loss is usually followed by grave consequences. McCaughan1 has recently discussed the factors involved in the death resulting from complete drainage of pancreatic juice to the outside in experimental animals. It appears that, save for the terminal increase in urea of the blood, there is little demonstrable alteration in the blood, on chemical examination. The loss of water in the daily secretion of pancreatic juice, which amounts to from 300 to 450 cc., was thought to be an important factor in the fatal outcome. Pancreatic juice given by mouth in these studies had a beneficial effect, whereas intravenous injection of the juice or the

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