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This book has been conspicuous on the diabetic horizon for the last twenty years. It was conceived during the preinsulin epoch, was developed during the insulin epoch, and now thrives in a period which the author has named the Hagedorn era. Indeed, its revision so soon after publication of the fifth edition was necessitated by the discovery of protamine insulin by the distinguished Hagedorn and his associates of Copenhagen, whose report was published in The Journal, Jan. 18, 1936. The Hagedorn era has already been shown to be an improvement for the diabetic patient. Protamine insulin, Joslin says, is the most notable advance in the treatment of diabetes since the discovery of insulin in 1921. The action of regular insulin was dramatic in lowering the blood sugar, but its effect was temporary and most cases required two, three or even four injections a day. With protamine insulin the injections may
The Treatment of Diabetes Mellitus. JAMA. 1937;109(5):383. doi:10.1001/jama.1937.02780310061024