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To the Editor:—
In their paper on picrotoxin in the treatment of barbiturate poisoning in The Journal, July 31, Kline, Bigg and Whitney state: "The importance of picrotoxin in the treatment of this patient must be weighed carefully, as recoveries do occur in severe cases when nothing more than general supportive measures are employed."Chang and Tainter (Unusual Case of Barbital Poisoning with Recovery, The Journal, April 18, 1936, p. 1386) reported a case in which recovery occurred from the effect of 270 grains (18 Gm.) of sodium barbital, and Gwathmey (The Barbiturates: The Safe Preliminary Medication for Surgical Operations, ibid., Nov. 17, 1934, p. 1536) has reported a recovery from 172 grains (11 Gm.) of ipral. I have reported a case (Paraldehyde and Other Preliminary Hypnotics, Ancsth. & Analg.15:14 [Jan.] 1936) in which the patient recovered after taking 168 grains (11 Gm.) of sodium amytal, and Alexander
Miller AH. PICROTOXIN IN THE TREATMENT OF BARBITURATE POISONING. JAMA. 1937;109(10):809. doi:10.1001/jama.1937.02780360057022