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October 9, 1937

THE CLINICAL AND PATHOLOGIC IDENTITY OF PHEOCHROMOCYTOMAREPORT OF A CASE

Author Affiliations

DULUTH, MINN.

From the Department of Pathology, St. Luke's Hospital.

JAMA. 1937;109(15):1176-1180. doi:10.1001/jama.1937.02780410014004
Abstract

During the last decade, the dramatic and diagnostic clinical manifestations of a new disease entity have been established beyond a doubt. Although isolated important characteristics of this malady were described earlier by several authors,1 the first complete study of a classic case is that of Labbé, Tinel and Doumer2 in 1922. Since then, with ever increasing frequency, twenty-seven new case reports, all fundamentally clinical and pathologic duplicates, have appeared in the literature: The characteristic symptoms of thirteen3 of these patients completely disappeared following the surgical removal of a benign tumor composed of the epinephrine-producing cells normally found in the adrenal medulla. Necropsy or fatal surgery revealed the same neoplasm in the remainder of this group.4

Fifty-five additional reports of tumors of the same cells have been found. These may be divided into three groups of nearly equal size. In one, no clinical history was given, while

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