Triple primary carcinoma is a very rare entity. Warren and Gates1 published statistics on 1,259 verified cases of multiple primary neoplasms which were taken from the records of approximately 115,000 postmortem examinations. In these 1,259 cases there were only thirty-seven instances in which there were more than two primary malignant tumors in one individual. All thirty-seven were triple carcinomas. This made an incidence of 2.9 per cent of primary triple neoplasms in their series of multiple primary tumors. On the basis of all statistics available both here and on the continent the frequency of multiple malignancy is 1.84 per cent of cancer cases. At the Mayo Clinic, where the incidence of malignancy is probably higher than in general hospitals, Hanlon2 recently added forty-nine cases of double primary carcinoma, but in no one patient did he find a record of three primary neoplasms.
The criteria necessary for the
DROOKER JC. TRIPLE PRIMARY CARCINOMA IN OTOLARYNGOLOGY. JAMA. 1937;109(15):1180-1184. doi:10.1001/jama.1937.02780410018005