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October 9, 1937

Current Comment

JAMA. 1937;109(15):1203-1204. doi:10.1001/jama.1937.02780410041013

RELATION OF NICOTINIC ACID TO HUMAN PELLAGRA  Since the classic series of investigations on the relation of diet to pellagra begun in 1914 by Goldberger and his collaborators of the United States Public Health Service, investigators have been attempting to concentrate and purify the dietary factor concerned in the prevention of human pellagra. The progress of these studies was greatly facilitated by the work of Chittenden and Underhill.1 These investigators, using diets similar to those associated with human pellagra, were able to produce experimental blacktongue in dogs. They demonstrated that this disease was similar to, if not identical with, human pellagra. Conditions were thus provided for assaying experimentally the various fractions obtained during efforts to concentrate and identify the antipellagra dietary factor. Highly active concentrates have been prepared by a number of investigators. Recently, workers at the University of Wisconsin, in a preliminary note,2 have reported the isolation,

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