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This monograph presents the results of a study of the electrocardiographic changes in persons with orthostatic circulatory insufficiency. Forty-five such patients were studied and compared with 200 normal adults used as controls. The correlations were carried out on a mathematical statistical basis. In orthostatic circulatory insufficiency, the acceleration of the heart, the decrease in pulse pressure, the rise in diastolic and the fall in systolic pressures are greater than normal on standing up and symptoms of cerebral anemia are more frequent. The author concludes that there is a greater frequency of flattening and inversion of the T wave in leads 2 and 3 on assuming the upright position when there is orthostatic circulatory insufficiency than when this condition is absent. In addition to the T wave change, the ST becomes depressed. Immersion of two patients under water to counteract the effect of hydrostatic pressure prevented the occurrence of the electrocardiographic
Über Veränderungen des Elektrokardiogramms bei orthostatischer Zirkulationsstörung. JAMA. 1937;109(15):1224. doi:10.1001/jama.1937.02780410062026