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October 16, 1937


JAMA. 1937;109(16):1295. doi:10.1001/jama.1937.02780420055026

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To the Editor:—  I have read with great interest the editorial on "Cevitamic Acid Stimulation of Specific Antibody Production" in The Journal, August 28. Unless I am mistaken, Dr. Bernard L. Oser and I were the first to report that cevitamic acid, when administered in sufficient dosage, altered the immunologic responses in guinea-pigs. We demonstrated the fact that larger doses of cevitamic acid reduced and inhibited the susceptibility of the guinea-pig's skin to experimental sensitization with neoarsphenamine, and that the dose necessary to achieve this effect was higher than the minimal dose necessary to protect against scurvy. The publication by Oser and myself, which appeared in the Proceedings of the Society for Experimental Biology and Medicine (32:716 [Feb.] 1934) is, as far as I have been able to ascertain, the earliest report of experimental work dealing with the influence of cevitamic acid on immunologic mechanisms. This report was amplified

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