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October 16, 1937

Anestesia de base pela dialilmaloniluréa. (Estudo clinico e experimental.)

JAMA. 1937;109(16):1303. doi:10.1001/jama.1937.02780420063033

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This work, in Portuguese, deals with almalonylurea, a compound (diallylbarbituric acid, curral, diallylmalonylurea or dial) which is already used in general surgery. After experiments with animals, by using dial, the drug was tried as a preanesthetic hypnotic, basal anesthetic and general anesthetic. Its action was compared with several other general anesthetics, especially barbituric compounds which have similar pharmacologic characteristics. Dial is classified among the narcotics of medium strength; it has an anesthetic effect of longer duration than sodium evipal or eunarcon, and of shorter duration than somnifen and pernocton. Dial may be administered intravenously by slowly injecting a solution of the drug into a vein in the arm, and it also may be administered intramuscularly or orally. The dosage varies according to the individual and whether or not the effect desired is a basal anesthesia or a preanesthetic hypnosis. As a basal anesthetic the dose is 1 cc. (0.1 Gm.)

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