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October 23, 1937

CHOLESTEROL AND ATHEROSCLEROSIS

JAMA. 1937;109(17):1382-1383. doi:10.1001/jama.1937.02780430060024

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Abstract

To the Editor:—  In the clinical lecture on "Disturbance of the Cardiovascular System in Nutritional Deficiency" by Drs. Soma Weiss and Robert W. Wilkins (The Journal, September 4, p. 786) occurs the following sentence: "It has been amply demonstrated that feeding of cholesterol to certain species of animals can induce atherosclerosis or, rather, 'cholesterinsteatosis,' and through it heart disease." Cholesterinsteatosis indeed! The implication, as I take it, is that the condition produced in rabbits by cholesterol feeding is analogous to the lipoidoses, marked by the diffuse permanent storage of fats in the tissues. It is true that in the attempt to produce rapidly atherosclerosis in rabbits there is established a temporary steatosis. When cholesterol feeding is discontinued that condition progressively subsides and there remains a permanent disease of the arteries, a true atherosclerosis, corresponding to the natural disease in man. For example, a rabbit had been fed 74 Gm. of

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