In the discussion of Dr. Frederick T. Hill's paper on "The Management of Malignant Disease in a Small Hospital," read before the Eastern Section of the American Laryngological, Rhinological and Otological Society last January, Dr. Perry G. Goldsmith reported a case of malignant nasal sinus disease in which exophthalmos developed after irradiation. In this discussion, Dr. Goldsmith emphasized our lack of knowledge concerning the pathology, the course and the prognosis of exophthalmos occurring as a result of irradiation.
The literature is indeed scanty. Although New1 in 1926 reported the loss of eleven eyes in ninety-seven cases of malignant disease of the nasal sinuses, he did not specifically say that they were lost as the result of destructive changes secondary to irradiation. Ohngren2 discussed injuries to the eye following his combined electrosurgical operation, both with and without irradiation, and he attempted to classify these injuries into two groups: first,
SCHALL LA. EXOPHTHALMOS COMPLICATING IRRADIATION. JAMA. 1937;109(19):1506-1509. doi:10.1001/jama.1937.02780450010003