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November 6, 1937

ELIXIR OF SULFANILAMIDEMASSENGILLCHEMICAL, PHARMACOLOGIC, PATHOLOGIC AND NECROPSY REPORTS; PRELIMINARY TOXICITY REPORTS ON DIETHYLENE GLYCOL AND SULFANILAMIDEI

JAMA. 1937;109(19):1531-1539. doi:10.1001/jama.1937.02780450035011
Abstract

I INTRODUCTION  On Monday, October 11, telegrams were received from Dr. James Stevenson, president of the Tulsa County Medical Society, and from the Springer Clinic of Tulsa, stating that six deaths had occurred following the administration of Elixir of Sulfanilamide-Massengill, all cases having in common the pathologic condition of complete anuria. The telegrams inquired concerning the composition of the Elixir of Sulfanilamide-Massengill. In response, information was telegraphed that no product of the S. E. Massengill Company stands accepted by the Council on Pharmacy and Chemistry and that the Council had recognized no solution of sulfanilamide. The reason for the latter statement is that the Council is not in position to accept a solution of sulfanilamide until there is adequate evidence that it is both stable and does not contain toxic material in the doses recommended. The A. M. A. Chemical Laboratory immediately sent for specimens of Elixir of Sulfanilamide-Massengill. Two specimens

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