Iodobismitol contains 6 per cent of sodium iodibismuthite and 12 per cent of sodium iodide. The original solvent, ethylene glycol, has been replaced recently by propylene glycol, and 4 per cent of saligenin has been added as a local anesthetic. Iodobismitol was introduced by Hanzlik1 in 1932 after prolonged experimental study. The preparation was first used clinically by Mehrtens and Pouppirt,2 who reported favorable results in the treatment of neurosyphilis. The rapid involution of both early and late syphilis after the administration of iodobismitol was observed by Strandberg and Sjögren.3 No reports of the use of this preparation in the routine treatment of syphilis have been made as yet.
During the last six years iodobismitol has been used almost to the exclusion of other bismuth compounds in the Syphilis Clinic of the Stanford University School of Medicine. More than 125,000 injections have been given to approximately 3,000
BARNETT CW, KULCHAR GV. IODOBISMITOL IN THE TREATMENT OF SYPHILIS. JAMA. 1937;109(21):1715-1718. doi:10.1001/jama.1937.02780470037010