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This Russian work presents several papers based on the study of 153 cases of venereal lymphogranuloma treated at the institute between 1928 and 1935. The observations recorded are much the same as those observed in our clinics. The authors point out the preponderance of the disease in the male (85 per cent) and the occurrence of abortive and asymptomatic forms, particularly in women. The reaction of Frei was found to be of great practical importance in the diagnosis of difficult cases. All their cases of esthiomene (genito-anorectal elephantiasis) were preceded at some time, usually long past, by lymphogranuloma. The reaction of Frei was positive in twenty-four of twenty-five cases. The disease was far more predominant in women. Best therapeutic results were obtained from roentgenotherapy followed by surgical intervention. The authors consider genito-anorectal elephantiasis as a stage of the fourth venereal disease.
Chetvertaya venericheskaya bolezn; bolezn Nikola i Favra. JAMA. 1937;109(21):1752. doi:10.1001/jama.1937.02780470074036