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November 27, 1937

L'anaphylaxie: Expérimentale et humaine

JAMA. 1937;109(22):1840. doi:10.1001/jama.1937.02780480072031

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Abstract

This short monograph is a summary of the work on anaphylaxis by Pasteur Vallery-Radot and his associates since 1929. The five pages of references are exclusively of the latter authors. The work, of an experimental and clinical nature, embodies some of the well known facts in anaphylaxis and allergy. Briefly stated, anaphylaxis in animals (rabbits used) is always induced and is characterized by clinical shock, prolonged fall in blood pressure, vasoconstriction (peripheral and mesenteric vessels) and a decreased coagulability of the blood. In man, induced anaphylaxis is rare (as after therapeutic administration of horse serum). However, the author classifies the various allergic manifestations in man as spontaneous anaphylaxis, notwithstanding the fact that the criteria given for anaphylaxis in animals are never seen in the allergic states of man. He recommends intradermal skin tests or the Prausnitz-Küstner reaction in the diagnosis of allergic states and has found clinically that daily intradermal

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