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The determination of serum iron has always presented technical difficulties which have been an obstacle to the thorough study of the iron deficiency state. This monograph concerns itself with not only the pathogenesis, symptomatology and treatment of conditions associated with iron deficiencies but also with methods for iron determination. The authors give a detailed description of their method in the first part of their monograph. The values for a small group of normal men and women are given and no direct relationship was found between the hemoglobin content of their blood and serum iron. Following the discussion on technic are clinical observations on acute and chronic posthemorrhagic anemias, primary hypochromic anemia, hemolytic anemia, leukemia, polycythemia vera and postinfectious anemias. The serum iron in tuberculosis and rheumatic fever is next discussed. The authors then discuss the metabolism of iron in normal and pathologic states. Treatment of the iron deficiency states conclude
Das Serumeisen und die Eisenmangelkrankheit (Pathogenese, Symptomatologie und Therapie). JAMA. 1937;109(22):1842. doi:10.1001/jama.1937.02780480074035