The treatment of nephrosis, the chronic renal disorder so peculiarly prevalent in childhood and adolescence and of which the exact etiology it still quite obscure, offers many perplexing problems to the practitioner.
Aside from its chronicity, one of the most disconcerting characteristics is its tendency to alternate remission and severe exacerbation and its reappearance after long periods of apparent cure.
Although considerable progress has been made in the treatment of the condition, no form of therapy is really consistently successful or gives assured relief for the more troublesome symptoms. Outstanding among these and most alarming are the excessive, sometimes huge, losses of protein in the urine and the development of anasarca and ascites to a degree hardly equaled by any other condition affecting the child.
The albuminuria cannot be treated but can be overtreated, much to the harm of the patient when it is made the excuse for excessive limitation
SCHLUTZ FW, COLLIER JL. THE TREATMENT OF NEPHROSIS IN THE YOUNG CHILD. JAMA. 1937;109(24):1959-1963. doi:10.1001/jama.1937.02780500015005