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April 30, 1932


Author Affiliations


From the Chemical Division of the Medical Clinic, the Johns Hopkins Hospital and University.

JAMA. 1932;98(18):1525-1531. doi:10.1001/jama.1932.02730440005002

Early in April, 1930, shortly after the announcement by Drs. W. W. Swingle and J. J. Pfiffner1 of their successful preparation of an extract from beef suprarenal cortex which would prolong the lives of bilaterally suprarenalectomized cats indefinitely, we were fortunate in making an arrangement with them whereby we sent an assistant, Mr. George Farrar, to Princeton to aid inthe manufacture of the extract during the summer of 1930, and in exchange received a supply of the cortical material for use in the study of patients with Addison's disease and for other purposes. This supply was furnished us for clinical use from Princeton until June, 1931. Since then we have been making the extract in our own laboratory. Our own material has essentially the same effect and potency as that produced in the Princeton laboratory, as judged by biologic assay on dogs2 and by its clinical effect on

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