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Article
May 7, 1932

NICOTINE AND THE LIVER

JAMA. 1932;98(19):1657. doi:10.1001/jama.1932.02730450051017
Abstract

A book on personal hygiene,1 reminds us that "the poetic effusions of the lovers of the weed are no safer guide than the exaggerated and intemperate pronouncements of people who have idiosyncrasies against tobacco and simply hate it." This volume points out that tobacco and its smoke contain powerful poisons. What we get when we smoke was described a decade ago in The Journal.2 A cigaret smoker who puffed away steadily for an hour might absorb as much as 36 milligrams of nicotine if he inhaled, and 27.5 if he only puffed—an amount sufficient certainly to cause ill effects.

It must be obvious to any one who contemplates the detrimental pharmacodynamic possibilities to which millions of contented smokers subject themselves daily that there must be some beneficent factor of safety at work to prevent or at least ameliorate the menace. One of these has recently been found to

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