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January 15, 1938

THE EFFECTS OF TOXIC DOSES OF BENZYL METHYL CARBINAMINE (BENZEDRINE) IN MAN

JAMA. 1938;110(3):206-207. doi:10.1001/jama.1938.62790030001010
Abstract

Benzedrine is a synthetic drug which is in common use today and frequently is taken without medical supervision. The benzedrine inhaler has been used extensively in infections of the upper respiratory tract; benzedrine solution has been used locally less frequently in this condition. Benzedrine sulfate has been used internally with success in the treatment of narcolepsy and in cases of orthostatic hypotension. It is interesting to note that in my experiments toxic doses of benzedrine sulfate produce orthostatic hypotension constantly for several hours after the original stimulation of the sympathetic nervous system has subsided.

In the experimental study of the effects of toxic doses of benzyl methyl carbinamine by inhalation, it is a most difficult task to determine the amount of the drug absorbed and its manner of destruction and elimination in the human body. It is important to note that the toxic doses used in the experiments given here

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