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To the Editor:—
In connection with the metrazol convulsive treatment of schizophrenia we recently encountered a phenomenon to which I think attention should be called.Ordinarily we expect the metrazol reaction to occur within less time than a minute after injection with the drug. In our experience the onset is usually from fifteen to twenty seconds later. We recently had a young man who was given a unit dose of 3 cc., to which he responded with fixed expression and staring lasting a matter of a few seconds, a fairly typical petit mal reaction from which he recovered as usual. At the time of the next treatment he was given 4 cc. of metrazol with even less reaction. On the third treatment he was given 5 cc. There was no question whatever about the drug being in the vein. In approximately fifteen seconds he showed an exceedingly mild clonic convulsion,
McAdoo HW. METRAZOL CONVULSIVE PHENOMENA IN DEMENTIA PRAECOX. JAMA. 1938;110(7):528. doi:10.1001/jama.1938.02790070052024