Following the favorable preliminary report by Schwentker, Gelman and Long,1 I began the use of sulfanilamide for meningococcic meningitis.
Five cases and one recurrence are reported here. There was no selection of cases; the infection varied from moderate to severe intensity; the ages of the patients were from 1 1/2 to 26 years. Since the site of the disease in meningitis is accessible by spinal puncture and the actual exudate of the affected part can be seen, measured, studied and counted, this disease is one of the few in which clinical bedside results can be correlated and confirmed by laboratory examinations. The error of human judgment and enthusiasm is, so to speak, counterbalanced by the results of examination in the pathologic laboratory. My results are summarized in the accompanying case reports. The clinical observations paralleled those of the laboratory.
The technic of these authors1 was used at first
WILLIEN LJ. SULFANILAMIDE THERAPY IN MENINGOCOCCIC MENINGITIS. JAMA. 1938;110(9):630–632. doi:10.1001/jama.1938.02790090012004