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May 21, 1938


Author Affiliations


From the Peripheral Vascular Clinic of the Israel-Zion Hospital.

JAMA. 1938;110(21):1746-1747. doi:10.1001/jama.1938.62790210003008b

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The rarity of thrombo-angiitis obliterans in women is revealed by the fact that a total of twenty-two case reports have appeared in the literature. We have recently had a very unusual experience in observing this disease in two sisters. To our knowledge this is the first observation of its kind. We are thus prompted to present the clinical histories.


Case 1.—  P. L., a Polish Jewess, aged 34, who came under observation on Sept. 4, 1937, had noticed five years before that walking produced an aching pain and cramps in her feet and legs. Her claudication became progressively worse, so that at the time of examination she was unable to walk more than one-half block. The pain was relieved only after a few minutes of rest. She also complained of cold feet and noticed their pale appearance. She had formerly been employed as an artificial flower worker

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