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This brochure emphasizes the after-effects obtainable from blood transfusion, which are likened to parenteral alterative influence (umstimmunges therapie). Immediately following the transfusion there is a biphasic tendency: phase I with rising temperature, sympatheticotonia, increase in blood calcium, tendency to acidosis and a leukocytosis change in the direction of myeloid character, with increased basal metabolism and blood sugar. The second phase is characterized by the opposite tendencies: falling temperature, vagotonia, increased potassium in blood and alkalosis, lymphocytic increase and diminution in basal metabolism and the sugar content of the blood. This, however, is not the end of the changes, because the author has been able to detect protracted excitation processes which may reach their height between the fifth and fourteenth days after the transfusion and last as long as from three to four weeks. This shows itself especially in a secondary increase in erythrocytes, frequently with the appearance of reticulocytes. There
Die Bluttransfusion als Mittel zur therapeutischen Umstimmung. JAMA. 1938;110(21):1778. doi:10.1001/jama.1938.02790210058030