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The author states that the object of the book is to describe disruptive chemotaxis, indicating the power of certain hard substances to draw into them certain soft lining substances and to lay down a law "that whenever young fibrous tissue, particularly young blood vessels, come into contact with bone or a calcified deposit new bone formation occurs." Bone development is concisely reviewed. It is asserted that in the process of ossification calcium is always laid down first; then young fibrous tissue grows in and forms bone. This is true however only for enchondral ossification, so that the author is faced with the necessity of finding another explanation for intramembranous or fibrous ossification. A discussion of pathologic processes of ossification follows, but it is difficult to see wherein the author contributes anything more than a new phrase in his attempt to shed new light on the biophysical and biochemical processes of
The Rôle of Chemiotaxis in Bone Growth. JAMA. 1938;110(21):1779. doi:10.1001/jama.1938.02790210059036