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Article
July 2, 1932

Arbeiten aus der dritten Abteilung des Anatomischen Institutes der Kaiserlichen Universität Kyoto.

JAMA. 1932;99(1):64. doi:10.1001/jama.1932.02740530066042

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Abstract

The papers collected in this publication form the experimental justification for the treatment of tuberculous patients with "yatoconin." Funaoka and his school found a phosphatase and a pyrophosphatase in tuberculous tissue; they show that it is identical with the phosphatase that Robison discovered in ossifying cartilage. If a rabbit, infected with human tubercle bacilli, is given an intravenous injection of calcium diethyl phosphate, the phosphatase causes deposition of calcium phosphate in the tuberculous lesions. Injections of calcium levulose monophosphate ("yatoconin") were given to eighty patients with enlarged cervical lymph nodes. In from 8 to 12 per cent of the cases the nodes remained stationary; the remainder showed varying degrees of improvement after from fifteen to thirty injections. Good results are claimed for this treatment, even when it does not result in calcification. Funaoka expects to publish a third volume, which will give more clinical data. No opinion can be formed

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