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June 25, 1938


JAMA. 1938;110(26):2157-2158. doi:10.1001/jama.1938.02790260031014

The factors governing the amount of complement in the blood of animals, especially the guinea pig, have long been obscure. Observations have been reported relating variations in complement to seasonal changes, disease and diet. Among these the last has received increasing attention; it has been suggested that vitamin C intake is of major importance in determining the complement titer. The evidence on this point, however, has not been conclusive. Recently Ecker and his associates1 at Western Reserve University have reported extensive studies on the relation of vitamin C to complement. Many of the investigations on complement titer have been complicated by the difficulty of determining accurately the amount of this agent in a given sample of blood.1a In titrating complement, washed sheep erythrocytes and heated antiserum (obtained by injecting rabbits with sheep cells) are mixed, and the minimal amount of unheated guinea pig serum which must be added

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