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Combined Antidiphtheria and Antityphoid Vaccination
Mr. Dopter, a bacteriologist and a former director of the army medical department, presented recently to the Academy of Medicine an important communication on the reinforcement of immunity, in antidiphtheria vaccination, by the association with it of antityphoid vaccination. His researches were begun in 1930, and the army, in which vaccinations are compulsory, furnished an excellent field of observation. He first employed antidiphtheria vaccination by means of the Ramon anatoxin, in three injections, given at intervals of fifteen days, which enabled him to secure 95 per cent of immunization, as confirmed by the Schick test and the determination of the antitoxin content of the blood serum. He improved these results by employing a new and richer anatoxin, in accordance with the experiments carried out by Ramon, Debré and Mozer, at the Hôpital maritime des enfants, at Berck. With two injections, the proportion of successful immunizations
PARIS. JAMA. 1932;99(3):234-235. doi:10.1001/jama.1932.02740550048020