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The author begins with the assumption that schizophrenia is an organic disease and that some pathologic changes exist as a basis for it. In his research he utilized the functional tests of the reticulo-endothelial system, as he felt that the vascular system is the key to the understanding of schizophrenia. The author used the congo red method, which consisted in injections of a solution of congo red intravenously and the subsequent colorimetric estimation of the dye in the blood. The other method used is that known in the German literature as the Kauffmann method, which consists in the study of the exudate after application of the cantharides plaster to the skin (Kauffmann, F.: Die ortlich entzündliche Reaktionsform als Ausdruck allergischer Zustande, Krankheitsforschung, vols. 2 and 3, 1926). The author studied sixty cases of schizophrenia, twenty cases of organic brain disease, which consisted of dementia paralytica and epilepsy with mental deficiency,
Das retikulo-endotheliale System der Schizophrenen: Experimentellklinische Untersuchungen zum Schizophrenieproblem.. JAMA. 1932;99(3):248. doi:10.1001/jama.1932.02740550062039