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August 6, 1938

RECOVERY OF A PATIENT WITH UNDULANT FEVER TREATED WITH SULFANILAMIDE

Author Affiliations

Boston

From the Medical Service of Beth Israel Hospital and the Department of Medicine, Harvard Medical School.

JAMA. 1938;111(6):521-523. doi:10.1001/jama.1938.72790320001011
Abstract

My purpose in this communication is to describe the rapid recovery of a patient with unquestionable undulant fever after the administration of sulfanilamide. The obstinacy with which this disease resists treatment, the tendency to relapse and the debilitating consequences of this infection are well recognized. The recovery in the case reported here and the occasional similar recoveries recorded in Europe following the use of sulfanilamide in undulant fever merit attention.

REPORT OF CASE1  A man aged 33, a meat packer, felt perfectly well until three weeks before admission, when he experienced malaise, anorexia and fever ranging from 99 to 102 F. On several occasions he experienced chills lasting from fifteen to twenty minutes and profuse perspiration. During the three weeks before admission he suffered increasing weakness and noted that the rise in temperature occurred every evening. When I saw the patient he appeared exhausted, torpid and flushed but in

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