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July 23, 1932

Krankheitserreger und Gewebsbefunde bei multipler Sklerose: Vergleichend-histologisch-parasitologische Untersuchungen bei multipler Sklerose und anderen Spirochätosen.

JAMA. 1932;99(4):331. doi:10.1001/jama.1932.02740560057047

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The author has long attempted to place multiple sclerosis on the basis of a spirochetal disease. He has described a short, thick spirochete in sections by the silver method and attained some success at transmission of this organism to the experimental animal. His experimental work has not been confirmed, although such men as Hideyo Noguchi have attempted it. Most histopathologists consider that the spirochetes in sections which Steiner describes are artefacts produced by the silver or fragmented pieces of axis cylinders. In the present volume the author attempts to show a similarity of the histology of dementia paralytica, with its large areas of perivascular demyelinization, with that of multiple sclerosis, and by such procedure strengthen his conception that multiple sclerosis is a spirochetal disease. The work adds nothing that his previous publications have not brought out, and this monograph is interesting only to the worker in the special field.

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