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September 17, 1938

UNDULANT FEVER TREATED WITH SULFANILAMIDE

Author Affiliations

Chicago; Oak Park, Ill.

JAMA. 1938;111(12):1092-1093. doi:10.1001/jama.1938.72790380001008
Abstract

Sulfanilamide was originally found successful in the treatment of infection produced by gram-positive organisms. It is also effective in controlling infections due to gram-negative bacteria.

Berger and Schnetz1 used it in the management of brucellosis. Stern and Blake2 report three cases in which cure resulted with the drug. They were apparently unaware of its previous use in brucellosis, since they gave no bibliography. Working independently, we had found it beneficial in two cases of undulant fever. Our report, submitted to The Journal in January 1938, was rejected and returned in April. Sulfanilamide was furnished to us by the Winthrop Chemical Company.

Case 1.—  H. K. worked in the stockyards as a truck driver, handling both raw pork and beef. He entered Cook County Hospital in April 1937. Before admission he had been sick three weeks with chills, fever, sweating, generalized aching and weakness. His temperature continued to fluctuate

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