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September 17, 1938

Die Methoden der experimentellen Chemotherapie

JAMA. 1938;111(12):1129. doi:10.1001/jama.1938.02790380071030

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This is a practical manual of selected methods such as might be used in organizing a chemotherapeutic institute or in a course on chemotherapeutic experiments on animals. Methods of the greatest importance in producing infections arc given in detail, those little used being merely referred to; choice of chemical compounds is limited to the well tried and tested, derivatives being dealt with briefly.

The supreme law of chemotherapy, according to the author, is that the drug must not injure the host. For this reason, every therapeutic experiment must be preceded by a pharmacologic experiment which determines the minimum fatal dose and the highest tolerated dose of a drug. The aim of chemotherapy is to destroy the parasites in the host or at least to injure them so that they may be rendered harmless by the natural processes of the host. He warns that few infectious diseases in man run the

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