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This monograph is devoted to the exposition of the hypothesis that bone and dentin changes in such diseases as rickets, achondroplasia, scurvy, experimental hyperparathyroidism, Paget's disease and osteogenesis imperfecta are markedly influenced by two factors. One of these operates on rapidly growing normal tissues particularly during the developmental stage, when proliferation is greatest, tending to arrest growth and retard orderly development (differentiation) of embryonic types of cells from youthful forms to mature ones. The other acts on fully grown, working cells in which proliferation has ceased causing a dedifferentiation of them to less mature forms (metaplasia) and followed by proliferation. It is asserted that the changes in rickets and achondroplasia are typical of the first type of change, osteogenesis imperfecta and scurvy of the second. It is apparent that the author's point of view has been greatly influenced by the work of Häggqvist and his theory of bone calcification and
Tissue Reactions in Bone and Dentine: A Morpho-Biological Study of the Formation and the Dissolving of Bone and Dentine. JAMA. 1938;111(12):1130. doi:10.1001/jama.1938.02790380072033