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To the Editor:—
In reference to the editorial comment "Contraindicated Bacteriophage Therapy" (The Journal, August 6) I am glad to find this problem brought to the attention of the medical profession.In my hands, bacteriophage therapy has frequently been distinctly beneficial against staphylococcic infections when used locally. I have had little experience with antistreptococcus bacteriophages because of their extreme specificity. For each case, however, bacteriophage was not employed until it had been developed on the particular infecting organism and had reached a high level of efficiency (at least 1 × 10-7 by serial dilution) against it. This was achieved by a process of repeated contacts and filtrations (Goldsmith, N. R.: A Procedure for the Preparation of Autogenous Bacteriophage for Therapy, in Clinical Laboratory Methods and Diagnosis, St. Louis, C. V. Mosby Company, 1935, pp. 770-771).Further, frequent tests were made of the effectiveness of the bacteriophage against later cultures
Goldsmith NR. "CONTRAINDICATED BACTERIOPHAGE THERAPY". JAMA. 1938;111(13):1230-1231. doi:10.1001/jama.1938.02790390086029