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In the application of local antiseptics to disorders of the urinary tract, a twofold purpose must be kept in view; first the destruction of the infecting microorganisms, and second the stimulation of a reaction in the tissues of the patient which will enable him to offer the necessary resistance to the infection. It is now generally recognized that the stimulation of the natural resistance of the mucous membrane of the urinary tract is quite as important as the destruction of the infective agents. If, for example, an antiseptic is wrongly used in the urethra, it may, while slaying the gonococcus, incidentally so damage the normal epithelium as to invite future stricture formation. Rightly used, it will offer the mucous membrane just enough irritation to stir it to defend itself but no more. This happy mean is what the urologist is seeking. In the past the physician's zeal to kill off
WALTHER HWE. LOCAL URINARY ANTISEPTICS. JAMA. 1938;111(16):1465–1469. doi:10.1001/jama.1938.72790420007012a