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October 15, 1938

HIPPURIC ACID TEST AS AN INDEX OF HEPATIC DAMAGE

JAMA. 1938;111(16):1470-1471. doi:10.1001/jama.1938.02790420050015
Abstract

Since the classic investigations by Bunge and Schmiedeberg in 1877 it has been believed that synthesis of hippuric acid takes place in the kidney exclusively. More recent researches make it appear that this synthesis, at least in man, takes place in the liver as well. The conjugation of benzoic acid with aminoacetic acid to form hippuric acid represents one of the several mechanisms by means of which the liver detoxifies certain noxious substances brought to it from the gastrointestinal tract. Quick1 found that the excretion of hippuric acid proceeded at a constant rate regardless of the amount of sodium benzoate ingested but that such excretion could be greatly increased by the ingestion of aminoacetic acid. He concluded, therefore, that the quantity of hippuric acid excreted per hour represented the maximum capacity of the organism to synthesize aminoacetic acid. Since aminoacetic acid is said to be formed in the liver,

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