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Dr. Castagnou's monograph describes a number of excellently planned and executed experiments on the hypoglycemic action of insulin on dogs. The study is in several parts. The first is devoted to the investigation of the characteristics of hypoglycemic curves in the normal dog after intravenous and subcutaneous injection of insulin. In executing these, as well as in the subsequent experiments, the author made use of the method devised by Trinquier and modified by Aubertin. He also describes a new measure for the intensity of the hypoglycemic reaction to injected insulin, which is intended to supplement the index of assimilation of Norgaard and Thayssen. This is the angle formed by lines drawn tangent to the assimilation and restoration curves.
A second series of experiments concern themselves with the variations in the hypoglycemic action of insulin, after partial or total pancreatectomy. The principal result here is the observed regularity of the assimilation
Action hypoglycémiante de l'insuline chez le chien sous l'influence de la pancréatectomie, de la dégénérescence exocrine du pancréas après ligature des canaux et du jeûne prolongé. JAMA. 1938;111(19):1791-1792. doi:10.1001/jama.1938.02790450073032