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November 19, 1938

RADIOSENSITIVITY OF MALIGNANT NEOPLASMS OF THE UTERINE CERVIX

Author Affiliations

ROCHESTER, MINN.

From the Section on Therapeutic Radiology, the Mayo Clinic.

JAMA. 1938;111(21):1902-1907. doi:10.1001/jama.1938.02790470014004
Abstract

Carcinoma of the uterine cervix is radiosensitive. Radiosensitivity means sensitive to radiant energy; specifically it is used to describe certain tumors that are susceptible of being injured or destroyed by radium and roentgen rays. This fact was soon learned by the early workers in the field of radium therapeutics. The disease was among the first malignant tumors observed to be amenable to the rays of radium.

The radiosensitivity of the lesion under consideration is relative, since the degree of injurability or destroyability is dependent on many factors. Apparently some of these factors can be evaluated, at least in a measure or in a limited degree. Ewing said: "The general condition of the patient determines the result of radiation, regardless of nearly all other factors. In fresh subjects in good general health, without anemia or cachexia, the results of radiation are usually prompt and definite, whereas in anemic and cachectic subjects

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