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November 19, 1938

EXCRETION OF SULFANILAMIDE AND ACETYLSULFANILAMIDE IN HUMAN MILK

Author Affiliations

OMAHA

From the University of Nebraska College of Medicine, Department of Biochemistry.

JAMA. 1938;111(21):1914-1916. doi:10.1001/jama.1938.02790470026007
Abstract

With the introduction and widespread use of sulfanilamide in the treatment of puerperal infections, much work has been done on the effect of the drug on the sick mother.1 The excretion of the drug in men and in nonlactating women has also been studied extensively,2 but I have been unable to find any work on the excretion of sulfanilamide in the lactating human mother. This work was undertaken to study the possibility of excretion of sulfanilamide in human milk and to determine, if possible, the amount of both sulfanilamide and the conjugated form of sulfanilamide which are known to be present in human blood3 and, therefore, could possibly be present in human milk.

PROCEDURE  The method described by Marshall2 in which alcohol is used as a protein precipitant cannot be applied to milk because of the high fat content of milk. An appreciable amount of fat

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