Discrepancies between the microscopic diagnosis and the clinical behavior of tumors are not infrequent. Cole1 has recently cited many examples of gastric ulcer in which the estimation of malignancy varied decisively among various diagnosticians. A newer and more difficult problem concerns the diagnosis of tumors of the bronchi.
Formerly tumors of the lung were considered rare and quite unsusceptible of surgical attack, even when benign. Now, however, the point of view has changed. Not only are benign tumors considered suitable for successful surgical excision but even malignant neoplasms have been shown to be removable with comparative safety and with a reasonable chance of cure. With the emphasis on early diagnosis has come the identification of the early clinical manifestation of these tumors. The symptoms produced by pulmonary tumors are now becoming more generally known. With the advent of bronchoscopy their early stages are actually seen and biopsy specimens obtained
MIXED TUMORS OF THE LUNG. JAMA. 1938;111(21):1939-1940. doi:10.1001/jama.1938.02790470051015