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This is a monograph in which the role of calcium oxalate in relation to stone formation in the urinary tract is exhaustively studied. Many tables are presented in demonstrating the physical properties of calcium oxalate in relation to solubility. The various effects of magnesium intake and urinary magnesium excretion on the formation of calcium oxalate stones are forcefully stressed. In animal experiments using rats, stone formation was frequent when the urinary magnesium excretion was lowered with coincidental increased calcium and oxalic acid excretion. However, if vitamin A and D deficiency was added to the foregoing conditions, stone formation was still greater and damage to the renal parenchyma more marked. An acid producing diet reduced definitely the incidence of stone formation. The frequency of stone formation in a large series of animals was greater in the male, coinciding with a higher urinary calcium output in the male sex. Males showed in
Eine experimentelle Studie über Calciumoxalat als Steinbildner in den Harnwegen: Speziell mit Rücksicht auf die Bedeutung des Magnesiums. JAMA. 1938;111(21):1957-1958. doi:10.1001/jama.1938.02790470069031