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December 31, 1938

Vitamin Bi (Thiamin) and Its Use in Medicine

JAMA. 1938;111(27):2512. doi:10.1001/jama.1938.02790530066025

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The growth promoting and antineuritic values of different foods, such as yeast and liver, originally were considered to be the properties of a single substance. Now it is known that the antineuritic substance is one factor, called vitamin B1 or thiamin. The growth promoting value is due to several factors. Vitamin B1 and three other substances are included in the heat labile fraction of the vitamin B complex. The heat stable fraction includes riboflavin, nicotinic acid, vitamin B6 and several other substances which, unlike the preceding three, are not readily adsorbed from an aqueous solution. Throughout the present monograph the authors have carefully considered the relationship of vitamin B1 the subject of their study, to the other factors of the B complex, as far as they are known.

The antineuritic factor of foods was first clearly recognized by Eijkman in 1897. By 1915 investigations had proceeded

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