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From reading the first part of this work, one may deduce that the author, more in desperation than anything else, treated a patient who had severe migraine and epileptic equivalents with a 20 per cent solution of sodium chloride and bromide and observed considerable relief in symptoms. Thereupon he applied this method of treatment to thirty-five epileptic and seven migrainous patients, experimenting a little with different methods of administration and also with magnesium sulfate. Finally he seems to have hunted around for a possible explanation of the effects observed. He found this medication (sodium chloride 2 Gm., sodium bromide 2 Gm., sterile dis-dis tilled water 20 cc.) most effective in cases of status. By practicing the injections three times a week he was able to reduce the frequency of both the epileptic and the migrainous attacks. The author's principal experimental work was the observation of the fall in cerebrospinal fluid
Essai de traitement de la migraine et de l'épilepsie par les solutions hypertoniques: Etude clinique et expérimentale. JAMA. 1938;111(27):2513-2514. doi:10.1001/jama.1938.02790530067034