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The Council on Pharmacy and Chemistry of the American Medical Association suggested the probability that the drug "causalin," recommended for the treatment of arthritis, contains aminopyrine.
We feel that this drug was responsible for the production of agranulocytosis in the case presented here.
REPORT OF CASE
J. J. E., a white man aged 65, was admitted to the Georgetown University Hospital Dec. 6, 1937, and died the same day. His chief complaint on admission was "sore throat." Two weeks prior to admission he had a "cold" from which he apparently recovered. One week prior to admission he had a chill with fever. He thought that this condition was a recurrence of his previous "cold." Six days prior to admission he first noticed a sore throat, which was treated locally with mercurochrome. Three days before admission ulcerations were found in the pharynx, which was markedly edematous and congested. Gradually but rapidly
Dardinski VJ, Lyddane ES. AGRANULOCYTIC ANGINAREPORT OF A CASE DUE TO CAUSALIN. JAMA. 1939;112(2):134. doi:10.1001/jama.1939.62800020001008