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January 26, 1946


Author Affiliations


From the Department of Physiology, Northwestern University Medical School and Wesley Memorial Hospital.; Dr. W. M. Freeman and the Children's Memorial Hospital assisted in making the metabolic study in case 3. Dr. Robert W. Keeton and the Illinois Research Hospital gave access to the films taken in September 1944 in case 1.

JAMA. 1946;130(4):197-202. doi:10.1001/jama.1946.02870040013004

The effects of large doses of vitamin D on animals were described in detail some years ago.1 Since the amounts of vitamin D required to produce toxic effects were far beyond that necessary for the prevention or treatment of rickets, these results seemed, at the time of their presentation, to be largely of academic interest. However, the use of large doses of vitamin D in the treatment of arthritis has exposed a great number of people to the hazards of hypervitaminosis D. For this reason it is important to renew interest in the effects of vitamin D overdosage and to emphasize again, as others have done recently,2 the symptoms and consequences of its toxicity.

Some authors,3 in reporting on the use of vitamin D in the treatment of arthritis, have tended to minimize the seriousness of the toxic effects which it produced. Others4 have pointed out

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