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September 17, 1932


JAMA. 1932;99(12):1008. doi:10.1001/jama.1932.02740640050024

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Vaccination Against Yellow Fever  Dr. H. de Beaurepaire Aragão, head of the Instituto Oswaldo Cruz, recently published an article on the prevention of yellow fever by means of immunizing vaccines. Although the problem has been discussed ever since the time of Pasteur, it was not until recently that it was more clearly understood and later made practical. In the first attempts at immunization, the vaccines were prepared by killing the yellow fever virus (present in the organs of Macacus rhesus previously infected with yellow fever) with solution of formaldehyde. Later, chloroform, glycerin and phenol (carbolic acid) were used, instead of formaldehyde, as agents to kill the virus, without impairing its immunizing properties. But the immunity conferred by the formaldehyde vaccines was not lasting. In a review of the entire problem, it was found that the failure of the vaccines to lead to the development of antibodies was due to the

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