[Skip to Content]
[Skip to Content Landing]
Other Articles
February 2, 1946

TREATMENT OF TETANUS

JAMA. 1946;130(5):305. doi:10.1001/jama.1946.02870050057023

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor:—  These are some personal observations on the treatment of active tetanus. After the fall of Okinawa and the surrender of many Japanese there were many wounded with active tetanus. They all had complete trismus, many with opistotonos, a few in coma.Our treatment at first consisted in giving tetanus antitoxin intraspinally, intravenously and intramuscularly. The routine consisted of once daily intraspinal and intravenous administrations and a four hour intramuscular sequence. There occurred no change in the clinical state, and after ten days of this treatment without progress we tried the effect of penicillin.The penicillin was given by once daily intraspinal and intravenous injection of 40,000 units and a four hourly intramuscular injection of 20,000 units. The improvement and eventual recovery following the institution of penicillin therapy was very impressive and warrants further investigation.

First Page Preview View Large
First page PDF preview
First page PDF preview
×