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To the Editor:—
Since the term "agranulocytosis" chosen by W. Schultz for the syndrome of diminished leukocytes in the blood means in its strict sense an increase in the nongranular leukocytes, it appears that a better term is necessary to designate this medical entity.Neutropenia is displacing the term granulocytopenia, which may occur in a mild or severe form with angina. It may be wise for clarity to substitute the term amyeloidemia for agranulocytosis when it refers to a complete absence of the myeloid series of white cells in the blood. Since all the cells of the myeloid series are involved in this syndrome the coined terms of aneutremia or aneutrophilemia, signifying the absence of neutrophils in the blood, is not warranted.The term amylemia, referring to the presence of hypothetical starch in the blood, appears in Stedman's Dictionary. The possible presence of amyloid in the blood, amyloidemia, is a
Seligman B. AMYELOIDEMIA VS. AGRANULOCYTOSIS. JAMA. 1946;130(8):530–531. doi:10.1001/jama.1946.02870080064024